ทีเอ็มซี คอนสตรัคชั่นManual assertion based on experiment ini, Reactome - a knowledgebase of biological pathways and processes,
Manually curated information which has been propagated from a related experimentally characterized protein.
Manual assertion inferred by curator fromi, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. Adenylyl cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.An evidence describes the source of an annotation, e.g. Manual assertion according to rulesi,
Manually curated information for which there is published experimental evidence.
This is known as the 'taxonomic identifier' or 'taxid'.,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from ADP , the pathway AMP biosynthesis via salvage pathway and in Purine metabolism . These are stable identifiers and should be used to cite UniProtKB entries. However, the requirement of huge computational resources for REMD, especially with the explicit solvent model, largely limits its application.
The information is filed in different subsections. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.,This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified').
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
It should be noted that while, in theory, two different sequences could For example, adenylate kinase (AdK), a monomeric phosphotransferase enzyme that catalyzes the phosphoryl transfer reaction (ATP-Mg 2+ + AMP ↔ ADP-Mg 2+ + ADP), undergoes a large-scale conformational change from open ( 9) to closed ( 10) to facilitate its substrate hydrolysis ( 11, 12 ). 8 22 24 This enzyme catalyzes the reversible reaction 2ADP↔ATP+AMP and may process metabolic signals associated with ATP use. These elements correspond to the DSSP secondary structure code 'T'.
,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.
,This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The enzyme has gained much attention recently because it can be used as a cell marker to replace ATP in the luciferase-based bioluminescence assay. Adenylate kinase , Adenylate kinase , Adenylate kinase (adk), Adenylate kinase This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism. Although vsREMD achieved results consistent with those from conventional REMD and experimental studies, the number of replicas required for vsREMD (30) was much less than that for conventional REMD (80) to achieve a similar acceptance rate (∼0.2), demonstrating high efficiency of vsREMD to characterize the protein conformational change and associated free-energy profile. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes).
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,Inferred from Biological aspect of Ancestor
Function i Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. a chemical reaction that the enzyme catalyzes.,This subsection of the Function section describes the interaction between a single amino acid and another chemical entity. Protein sequence database of the Protein Information Resource, Ensembl eukaryotic genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. The current subsections and their content are listed below:
,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
,The checksum is a form of redundancy check that is calculated Adenylate kinase (AK) is a ubiquitous and abundant enzyme catalyzing the phosphoryl transfer between two adenosine diphosphate (ADP) molecules to yield adenosine triphosphate (ATP) and adenosine monophosphate (AMP).
Several domains are described in this subsection.,Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.
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