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Two PCSK9 inhibitors are currently available in the UK and others are in the process of being developed. PCSK9 inhibitors may provide another treatment option … Two PCSK9 inhibitors are currently available in the UK and others are in the process of being developed. Drug images are also included. Drug information provided by: IBM Micromedex US Brand Name. For You News & Perspective ... More than 7100 monographs are provided for prescription and over-the-counter drugs, as well as for corresponding brand-name drugs, herbals, and supplements. They are sold under the brand names Repatha and Praluent. Repatha; Descriptions. Available for Android and iOS devices. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. List of PCSK9 inhibitors: View by Brand … They also appear to lower the risk of serious heart-related events by 15%. They are sold under the brand names Repatha and Praluent. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The PCSK9 inhibitor blocks the PCSK9 enzyme, resulting in more LDL receptors available to remove LDL from the blood, which produces in a decrease in LDL blood levels. Select one or more newsletters to continue. Peak plasma time: 3-7 days. For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). PCSK9 inhibitors. Alirocumab is a PCSK9 inhibitor produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture. They are not Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Potent cholesterol-lowering drugs known as PCSK9 inhibitors lower harmful LDL cholesterol by more than 50%. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Important: The information below refers to products available in the United States that contain alirocumab. Absolute bioavailability: 85%. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that binds to low-density lipoprotein receptors (LDL receptors), which stops LDL being removed from the blood, leading to an increase in blood levels of LDL. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The ones are can be used in the UK are Evolocumab and Alirocumab. Brand Name: Praluent; Last reviewed on RxList: 3/20/2020. PCSK9 inhibitors are a new class of drugs that lower LDL, or “bad,” cholesterol. Two other PCSK9 inhibitors are still being developed. Potent cholesterol-lowering drugs known as PCSK9 inhibitors lower harmful LDL cholesterol by more than 50%. We comply with the HONcode standard for trustworthy health information -. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. ... that targets proprotein convertase subtilisin kexin type 9 (PCSK9). Right now, there are two FDA-approved medications: alirocumab (Praluent) and evolocumab ( Repatha ). We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for alirocumab. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Two other PCSK9 inhibitors are still being developed. Brand Name and Other Names: Praluent Generic Name: Alirocumab Drug Class: PCSK9 Inhibitors. ... that binds to proprotein convertase subtilisin kexin type 9 (PCSK9). The only one on the market is the drug ezetimibe, available as a generic or as the name-brand Zetia. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. They also appear to lower the risk of serious heart-related events by 15%. They are not Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. What Is Alirocumab Used For and How Does it Work? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The PCSK9 inhibitor blocks the PCSK9 enzyme, resulting in more LDL receptors available to remove LDL from the blood, which produces in a decrease in LDL blood levels. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. PCSK9 is a serine protease that destroys LDLR in the liver, resulting in decreased LDL-C clearance and increased plasma LDL-C. PCSK9 inhibitors decrease LDLR degradation by PCSK9, and thereby improve LDL-C clearance and lower plasma LDL-C. Absorption. The ones are can be used in the UK are Evolocumab and Alirocumab. Distribution. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This class of drug can be given with statins and is usually for people at high risk of heart disease who have not been able to lower their cholesterol enough through other means. This drug can be combined with statins to produce faster results. They’re available in brand name and generic tablets and have become quite affordable. Vd: 0.04-0.05 L/kg Available for Android and iOS devices. Brand names: PraluentDrug class(es): PCSK9 inhibitorsAlirocumab systemic is used in the treatment of: → Search the entire Drugs.com site for alirocumab. Description and Brand Names. What are the names of PCSK9 inhibitors? PCSK9 Inhibitors. PCSK9 Inhibitors may be used along with diet and statin medications to lower low-density lipoprotein (LDL) cholesterol (also known as "bad cholesterol"). What are the names of PCSK9 inhibitors? They block the PCSK9 protein's ability to work, which helps the liver get rid of more bad cholesterol from … PCSK9 Inhibitors: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape Reference. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. PCSK9 inhibitors are designed to attach to a particular liver protein, which results in lowered LDL cholesterol. 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